Yes! You can get a free ISBN from Blurb if you make your book with BookWright, our Blurb Plug-in for Adobe InDesign, our PDF to Book workflow or Lightroom Classic (for Trade Books only).
Note that Blurb-supplied ISBNs will be registered under Blurb's name as the publisher of record, although you will be listed as the author and retain all rights to your book content. Blurb-supplied ISBNs cannot be re-registered to individual authors.
BookWright
While in BookWright, navigate to Distribution > Assign a Free ISBN.
Plug-in for Adobe InDesign
Using the Blurb Book Creator in InDesign, you can obtain a free ISBN by selecting the Blurb ISBN option. Note that Trade books are required to have an ISBN.
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PDF to Book
When uploading your PDF, select Blurb's Free ISBN from the dropdown menu of the ISBN section.
Lightroom Classic
ISBN are only available for Lightroom Trade books. After you design and upload your Lightroom Trade book you'll see the ISBN option.